Exam Code: ACRP-CP
Exam Name: ACRP Certified Professional Exam
Certification Provider: ACRP
Corresponding Certification: ACRP Certified Professional
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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Data Management and Informatics17%- Data collection
  • 1. Electronic data capture systems
  • 2. Case report form design and completion
- Data reporting
  • 1. Data integrity and security
  • 2. Database lock and data transfer
- Data quality control
  • 1. Query management and resolution
  • 2. Data validation and cleaning
Professionalism and Ethical Practice15%- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
- Continuous improvement
  • 1. Professional development and education
  • 2. Quality assurance and process improvement
Clinical Study Operations15%- Site management
  • 1. Study documentation and record keeping
  • 2. Site personnel training and delegation
- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
Study Design and Conduct17%- Study planning
  • 1. Sample size and statistical considerations
  • 2. Study population and eligibility criteria
  • 3. Protocol development and amendments
- Study implementation
  • 1. Study monitoring and oversight
  • 2. Investigational product management
  • 3. Site selection and activation
Ethical and Participant Safety Considerations19%- Clinical care and management of research participants
  • 1. Informed consent development and review
  • 2. Continuity of medical care
  • 3. Standard of care vs protocol requirements
- Ethical principles
  • 1. Human subject protections and privacy
  • 2. Clinical equipoise and therapeutic misconception
- Safety monitoring and reporting
  • 1. Safety information evaluation and communication
  • 2. Adverse event identification and classification
Regulatory and Compliance Requirements17%- ICH Guidelines
  • 1. E11 Pediatric Trials
  • 2. E9 Statistical Principles
  • 3. E6(R2)/E6(R3) Good Clinical Practice
  • 4. E2A Expedited Reporting
  • 5. E8 General Considerations for Clinical Trials
- International standards
  • 1. Declaration of Helsinki
- Compliance procedures
  • 1. Regulatory submissions and approvals
  • 2. Audits and inspections

ACRP Certified Professional Sample Questions:

The inclusion and exclusion criteria are in place so all subjects are:

  • A. Healthy and willing to complete the clinical trial.
  • B. Ethically vulnerable and patients with the disease under study.
  • C. Medically appropriate and protected from ethical vulnerability.
  • D. Patients with the disease under study and will not have any adverse events.
Reveal Solution  Discussion  0

Correct Answer: C  🗳️

Explanation: Only visible for VCE4Plus members. You can sign-up / login (it's free).

The CRC is prepared to consent a cognitively impaired participant to an Alzheimer's clinical trial. The CRC is required to utilize which of the following in the consent process?

  • A. A member of the research team
  • B. A witness
  • C. A family member
  • D. A legally acceptable representative
Reveal Solution  Discussion  0

Correct Answer: D  🗳️

Explanation: Only visible for VCE4Plus members. You can sign-up / login (it's free).

Which one of the following is a primary objective of a Phase III study of a new IP?

  • A. To demonstrate or confirm therapeutic benefit
  • B. To show superiority over another treatment
  • C. To establish dose information
  • D. To establish the safety profile
Reveal Solution  Discussion  0

Correct Answer: A  🗳️

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The sponsor calls the site and informs the research team that they have decided to temporarily suspend the study. What step should the research team take FIRST?

  • A. Inform the monitor of the termination of the study.
  • B. Inform the IRB/IEC of the study closure.
  • C. Inform participant and assure proper care is provided.
  • D. Schedule participant for early termination visit.
Reveal Solution  Discussion  0

Correct Answer: C  🗳️

Explanation: Only visible for VCE4Plus members. You can sign-up / login (it's free).

Per protocol, participants are scheduled to receive IP, which is calculated based on the participant's current weight. Unknown to the pharmacist, a participant recently lost 15 pounds and was overdosed as a result. What is the FIRST action the CRC must take to ensure the participant's safety?

  • A. Call the participant to return for an unscheduled visit.
  • B. Notify the PI.
  • C. Report a protocol deviation to the IRB/IEC.
  • D. Notify the sponsor.
Reveal Solution  Discussion  0

Correct Answer: B  🗳️

Explanation: Only visible for VCE4Plus members. You can sign-up / login (it's free).

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